Anti-CD35 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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CR1
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R06-4A-3
Isotype
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IgG
Reactivity
Application
Application Details
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IHC: 1/100-1/200
Immunogen
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A synthesized peptide derived from human CD35
Formulation
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Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Form
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Liquid
Gene ID
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1378
Uniprot ID
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P17927
Background
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CD35 is a type I single chain of glycoprotein, also known as C3b/C4b receptor, Complement Receptor type 1 or CR1. Four molecular weight allotypes (160kD, 190kD, 220kD, and 250kD) have been described. CD35 is expressed on granulocytes, monocytes, B cells, erythrocytes, and follicular dendritic cells, as well as subsets of NK and T cells. CD35 binds complement C3b, C4b, or iC3, and iC4, and plays important roles in both innate and adoptive immune response via mediating phagocytosis by granulocytes and monocytes. CD35 has also been reported to inhibit T-cell proliferation.
Research Area
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Tags & Cell Markers
Synonyms
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C3 binding protein; C3b/C4b receptor; C3BR; C4BR; CD35; CR1; KN