Anti-CD270 Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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TNFRSF14
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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9V6-Y7-K8
Isotype
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IgG1/Kappa
Reactivity
Application
Application Details
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FC：1/50-1/100
Immunogen
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Peptide
Molecular Weight
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–
Formulation
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Liquid in PBS, Glycerol and BSA
Form
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Liquid
Gene ID
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8764
Uniprot ID
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Q92956
Background
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Receptor for four distinct ligands: The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network. Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation. Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. In response to ligation of TNFSF14/LIGHT, delivers costimulatory signals to T cells, promoting cell proliferation and effector functions. Interacts with CD160 on NK cells, enhancing IFNG production and anti-tumor immune response. In the context of bacterial infection, acts as a signaling receptor on epithelial cells for CD160 from intraepithelial lymphocytes, triggering the production of antimicrobial proteins and proinflammatory cytokines. Upon binding to CD160 on activated CD4+ T cells, downregulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response.
Research Area
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Tumor biology
Synonyms
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TNFRSF14, HVEA, HVEM1, UNQ329/PRO509