Anti-CD133 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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PROM1
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R11-6J-6
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IHC: 1/100-1/200
Immunogen
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A synthesized peptide derived from human CD133
Molecular Weight
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Calculated MW:97kDa;Observed MW:133kDa
Formulation
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Liquid in PBS , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
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Liquid
Gene ID
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8842
Uniprot ID
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O43490
Background
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May play a role in cell differentiation, proliferation and apoptosis (PubMed:24556617). Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner.
Research Area
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Neuroscience
Synonyms
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AC133; CD133; CORD12; hProminin; MCDR2; PROM1; Prominin like 1; Prominin1; PROML1; RP41; STGD4