Anti-CD130 Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
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IL6ST
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
-
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IHC: 1/50-1/100
Immunogen
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A synthesized peptide derived from human CD130/gp130
Molecular Weight
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Calculated MW: 104 kDa; Observed MW: 130-140kDa
Formulation
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PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
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Liquid
Gene ID
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3572
Uniprot ID
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P40189
Background
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The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates the intracellular JAK-MAPK and JAK-STAT3 signaling pathways.
Research Area
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Cell Biology
Synonyms
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Interleukin-6 receptor subunit beta ,IL-6 receptor subunit beta,IL-6R subunit beta,IL-6R-beta, IL-6RB,CDw130