Anti-Caspase 6 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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CASP6
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R04-8C2
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 IP: 1/50 FC: 1/50-1/100
Immunogen
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A synthesized peptide derived from human Caspase-6
Molecular Weight
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Calculated MW: 33 kDa; Observed MW: 33 kDa
Formulation
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Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
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Liquid
Gene ID
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839
Uniprot ID
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P55212
Background
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Caspase-6 (Mch2) is one of the major executioner caspases functioning in cellular apoptotic processes. Upon apoptotic stimulation, initiator caspases such as caspase-9 are cleaved and activated. The activated upstream caspases further process downstream executioner caspases, such as caspase-3 and caspase-6, by cleaving them into large and small subunits, thereby initiating a caspase cascade leading to apoptosis. One of the major targets for caspase-6 is the membrane associated protein lamin A.
Research Area
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Cell Biology
Synonyms
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CASP6; MCH2; Caspase-6; CASP-6; Apoptotic protease Mch-2