Anti-Caspase 6 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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CASP6
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R04-5F9
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000
Immunogen
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Recombinant protein of human Caspase-6
Molecular Weight
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Calculated MW: 33 kDa; Observed MW: 11,33 kDa
Formulation
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50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Form
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Liquid
Gene ID
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839
Uniprot ID
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P55212
Background
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Caspase-6 (Mch2) is one of the major executioner caspases functioning in cellular apoptotic processes. Upon apoptotic stimulation, initiator caspases such as caspase-9 are cleaved and activated. The activated upstream caspases further process downstream executioner caspases, such as caspase-3 and caspase-6, by cleaving them into large and small subunits, thereby initiating a caspase cascade leading to apoptosis. One of the major targets for caspase-6 is the membrane associated protein lamin A.
Research Area
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Cell Biology
Synonyms
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CASP6; MCH2; Caspase-6; CASP-6; Apoptotic protease Mch-2