Anti-Caspase 11 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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Casp4
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R09-7H9
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IP: 1/20
Immunogen
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Recombinant protein of mouse Caspase-11
Molecular Weight
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Calculated MW: 43 kDa; Observed MW: 43,38,25 kDa
Formulation
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50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Form
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Liquid
Gene ID
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12363
Uniprot ID
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P70343
Background
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Proinflammatory caspase. Essential effector of NLRP3 inflammasome-dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators, such as UVB radiation, cholera enterotoxin subunit B and cytosolic LPS, as well as infection with Gram-negative bacteria. Independently of NLRP3 inflammasome and CASP1, promotes pyroptosis, through GSDMD cleavage and activation, and IL1A, IL18 and HMGB1 release in response to non-canonical inflammasome activators.
Research Area
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Cell Biology
Synonyms
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Caspl; ich-3; CASP-4; Casp11; CASP-11