Anti-CAPON Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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NOS1AP
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R05-9T-2
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IF: 1/50-1/200 FC: 1/50-1/100
Immunogen
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Peptide
Molecular Weight
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Calculated MW:56 kDa;Observed MW: 56 kDa
Formulation
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Liquid in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
Form
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Liquid
Gene ID
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9722
Uniprot ID
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O75052
Background
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Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity).
In kidney podocytes, plays a role in podosomes and filopodia formation through CDC42 activation (PubMed:33523862).
Research Area
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Neuroscience
Synonyms
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CAPON, KIAA0464,NOS1AP,Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein,C-terminal PDZ ligand of neuronal nitric oxide synthase protein,