Anti-CAMK2 Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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CAMK2A
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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3K6-E4-Y1
Isotype
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IgG1/Kappa
Reactivity
Application
Application Details
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WB：1/500-1/1000，ICC/IF：1/100-1/200
Immunogen
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Peptide
Molecular Weight
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Calculated MW: 54 kDa; Observed MW:54 kDa
Formulation
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Liquid in PBS, Glycerol and BSA
Form
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Liquid
Gene ID
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815
Uniprot ID
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Q9UQM7
Background
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The product of the CAMK2A gene is an enzyme that belongs to the serine/threonine-specific protein kinase family, as well as the Ca2+/calmodulin-dependent protein kinase II subfamily. Ca2+ signaling is crucial for several aspects of synaptic plasticity at glutamatergic synapses. This enzyme is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. According to a 2018 study by Bruno Reversade, the recessive mutation of CAMK2A in humans cause a syndrome of severe intellectual disability with growth retardation.
Research Area
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0
Synonyms
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CAMKA, KIAA0968