Anti-Butyryl-Histone H4 (Lys5) Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
-
H4C1
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
1F1-T5-X2
Isotype
-
IgG
Reactivity
Application
Application Details
-
WB：1/500-1/1000
Immunogen
-
Peptide
Molecular Weight
-
-
Formulation
-
Liquid in PBS, Glycerol and BSA
Form
-
Liquid
Gene ID
-
121504
Uniprot ID
-
P62805
Background
-
Histones are subject to a variety of enzyme catalyzed modifications, including acetylation, methylation, phosphorylation, ubiquitylation, etc. Butyrylation of lysine, structurally similar to lysine acetylation, is a newly identified reversible modification controlling protein activity. The reversible lysine butyrylation has been well demonstrated in both prokaryotes and eukaryotes in wide ranges of proteins including histones and non-histone substrates, such as p53. Similar to acetylation of histione H4 at lysine 12, butyrylation of histone H4 at lysine 5 may play a vital role in the epigenetic modulation, including chromatin remodeling and DNA transcriptional regulation.
Research Area
-
Epigenetics and Nuclear Signaling
Synonyms
-
H4K5bu