Anti-Butyryl-Histone H2B (Lys20) Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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H2BC4
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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6Q8-G5-B2
Isotype
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IgG
Reactivity
Application
Application Details
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WB：1/500-1/1000
Immunogen
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Peptide
Molecular Weight
-
-
Formulation
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Liquid in PBS, Glycerol and BSA
Form
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Liquid
Gene ID
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－
Uniprot ID
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P62807
Background
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Histones are subject to a variety of enzyme catalyzed modifications, including acetylation, methylation, phosphorylation, ubiquitylation, etc. Butyrylation of lysine, structurally similar to lysine acetylation, is a newly identified reversible modification controlling protein activity. The reversible lysine butyrylation has been well demonstrated in both prokaryotes and eukaryotes in wide ranges of proteins including histones and non-histone substrates, such as p53. Similar to acetylation of histione H4 at lysine 12, butyrylation of histone H2B at lysine 20 may play a vital role in the epigenetic modulation, including chromatin remodeling, and DNA transcriptional regulation.
Research Area
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Epigenetics and Nuclear Signaling
Synonyms
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H2BK20bu, Histone H2B.1 A；Histone H2B.a (H2B/a)；Histone H2B.g (H2B/g)；Histone H2B.h (H2B/h)；Histone H2B.k (H2B/k)；Histone H2B.l (H2B/l)