Anti-Butyryl-Histone H2A (Lys5) Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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H2AC4
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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9U4-H8-S2
Isotype
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IgG
Reactivity
Application
Application Details
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WB：1/500-1/1000
Immunogen
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Peptide
Molecular Weight
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-
Formulation
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Liquid in PBS, Glycerol and BSA
Form
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Liquid
Gene ID
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3012
Uniprot ID
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P04908
Background
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Histones are subjected to a variety of enzyme catalyzed modifications, including acetylation, methylation, phosphorylation, ubiquitylation, etc. Butyrylation of lysine is a newly identified reversible modification controlling chromosome structure and gene transcription. Lysine butyrylation is highly conserved in eukaryotic cells from worm to human. The unique structure and genomic localization of histone lysine butyrylation suggest that it is mechanistically and functionally different from histone lysine acetylation. Specifically, in both human somatic and rabbit male germ cell genomes, histone butyrylation marks either active promoters or potential enhancers. Butyrylation of histone H2A at Lys5 may play a vital role in the epigenetic modulation, including chromatin remodeling and DNA transcriptional regulation.
Research Area
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Epigenetics and Nuclear Signaling
Synonyms
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H2AK5bu, Histone H2A.2；Histone H2A/a；Histone H2A/m