Anti-BRD8 Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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BRD8
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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3L5-E8-Y6
Isotype
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IgG2a/Kappa
Reactivity
Application
Application Details
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WB：1/500-1/1000 IHC-P：1/50-1/100
Immunogen
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Peptide
Molecular Weight
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Calculated MW: 120 kDa; Observed MW:120 kDa
Formulation
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Liquid in PBS, Glycerol and BSA
Form
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Liquid
Gene ID
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10902
Uniprot ID
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Q9H0E9
Background
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May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.
Research Area
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Immunology
Synonyms
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SMAP, SMAP2