Anti-beta Amyloid 1-42 Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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A4
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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16D13
Isotype
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IgG2b
Reactivity
Application
Application Details
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WB: 1/500-1/1000 ELISA: 1/1000
Immunogen
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Human beta Amyloid peptide
Molecular Weight
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Calculated MW: 4.4 kDa; Observed MW: 90-130 kDa crosslinked with BSA
Formulation
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Liquid in PBS containing 0.09% sodium azide as a preservative.
Form
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Liquid
Gene ID
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351
Uniprot ID
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P05067
Background
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Amyloid-beta peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu2+ and Fe3+ to Cu+ and Fe2+, respectively. Amyloid-beta protein 42 is a more effective reductant than amyloid-beta protein 40. Amyloid-beta peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalyzed oxidation of lipoproteins. APP42-beta may activate mononuclear phagocytes in the brain and elicit inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation. Interaction with overexpressed HADH2 leads to oxidative stress and neurotoxicity. Also binds GPC1 in lipid rafts.
Research Area
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Neuroscience
Synonyms
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Abeta42，Amyloid-beta protein 42，Beta amyloid protein 42，Beta APP42，