Anti-BACE1 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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Bace1
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R03-9C8
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IP: 1/20
Immunogen
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Recombinant protein of mouse BACE1
Molecular Weight
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Calculated MW: 56 kDa; Observed MW: 70 kDa
Formulation
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50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Form
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Liquid
Gene ID
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23821
Uniprot ID
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P56818
Background
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Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. Cleaves APP with much more catalytic efficiency than for the wild-type.
Research Area
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Neuroscience
Synonyms
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ASP2; Bace; C76936