Anti-β-Catenin(E53K Mutant) Mouse Monoclonal Antibody

Anti-β-Catenin(E53K Mutant) Mouse Monoclonal Antibody
Anti-β-Catenin(E53K Mutant) Mouse Monoclonal Antibody
Anti-β-Catenin(E53K Mutant) Mouse Monoclonal Antibody
Anti-β-Catenin(E53K Mutant) Mouse Monoclonal Antibody

Anti-β-Catenin(E53K Mutant) Mouse Monoclonal Antibody

Mouse IgG Monoclonal for CTNNB1, CTNNB detection, Test with WB, IHC-P, ICC/IF, ELISA in Vertebrates

Reactivity
  • Vertebrates
Application
  • WB
  • IHC-P
  • ICC
  • IF
  • ELISA
Host
  • Mouse
Catalog Number
    ABXB07401
$680.00

Shipping To:
United States

Product Information

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Target
    CTNNB1, CTNNB
Host
  • Mouse
Storage
    Store at -20°C. Avoid repeated freezing and thawing
Clonality
  • Monoclonal
Clone Number
    2P5-A8-S4
Isotype
    IgG
Reactivity
  • Vertebrates
Application
  • WB
  • IHC-P
  • ICC
  • IF
  • ELISA
Application Details
    ELISA: 1/1000-1/5000 WB: 1/500-1/2000 IHC-P: 1/50-1/100
Immunogen
    A synthetic peptide from the internal region of β-catenin which includes the mutation of E53K, human origin.
Formulation
    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
Form
    Liquid
Uniprot ID
    ­
Background
    Beta-catenin (or β-catenin) is a protein that in humans is encoded by the CTNNB1 gene. β-catenin is a subunit of the cadherin protein complex and also acts as an intracellular signal transducer in the Wnt signaling pathway. Deregulation of beta-catenin signaling is an important event in the genesis of a number of malignancies, such as colon cancer, melanoma, hepatocellular carcinoma, ovarian cancer, endometrial cancer, medulloblastoma pilomatricomas, and prostate cancer.
Research Area
    Signal Transduction
Synonyms
    CTNNB1, CTNNB
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Product Image

Western blot analysis of recombinant β-catenin(E53K) and wild type proteins. Purified His-tagged β-catenin(E53K) protein (amino acids 1-76, lane 2) and corresponding wild type protein (lane 1) were blotted with Anti-β-catenin(E53K) mouse monoclonal.
Immunofluorescence of cells expressing β-catenin proteins with anti-β-catenin(E53K). HEK293T cells were transfected with pCDNA3-GFP- β-catenin (WT) plasmid (left column) or pCDNA3-GFP-β-catenin(E53K) plasmid (right column), then fixed and stained with Anti-β-catenin (E53K) monoclonal.