Anti-Axin 2 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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AXIN2
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R06-3A8
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000
Immunogen
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A synthetic peptide of human Axin 2
Molecular Weight
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Calculated MW: 94 kDa; Observed MW: 94 kDa
Formulation
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50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Form
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Liquid
Gene ID
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8313
Uniprot ID
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Q9Y2T1
Background
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Axin1 (Axis inhibition protein 1) and Axin2 are multidomain scaffold proteins that negatively regulate Wnt signaling. Axin1 interacts with APC, GSK-3β, Dvl, and β-catenin and promotes the GSK-3β-mediated phosphorylation and subsequent degradation of β-catenin .Down-regulates beta-catenin.
Research Area
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Cell Biology
Synonyms
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Axil; Axin like protein; Axin2; Axis inhibition protein 2; Conductin