Anti-ATP6V1B1 Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
-
ATP6V1B1
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
-
Isotype
-
IgG
Reactivity
Application
Application Details
-
WB: 1/500-1/1000 IF: 1/50-1/200
Immunogen
-
Recombinant fusion protein
Molecular Weight
-
Calculated MW:57kDa
Formulation
-
Liquid in PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Form
-
Liquid
Gene ID
-
525
Uniprot ID
-
P15313
Background
-
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain B subunit isoforms and is found in the kidney. Mutations in this gene cause distal renal tubular acidosis associated with sensorineural deafness.
Research Area
-
-
Synonyms
-
VATB; VMA2; VPP3; DRTA2; RTA1B; ATP6B1; ATP6V1B1