Anti-ATP Citrate Lyase (3D9) Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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ACLY
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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3D9-E9-H8
Isotype
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IgG2a
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IF: 1/50-1/200 FC: 1/50-1/100
Immunogen
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Purified recombinant human ATP-Citrate Lyase protein fragments expressed in E.coli.
Molecular Weight
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Calculated MW: 121 kDa; Observed MW: 121 kDa
Formulation
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Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Form
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Liquid
Gene ID
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47
Uniprot ID
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P53396
Background
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ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis.
Research Area
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Signal Transduction
Synonyms
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ACLY; ATP-citrate synthase; ATP-citrate; pro-S-)-lyase; ACL; Citrate cleavage enzyme