Anti-ATM(R2443Q Mutant) Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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ATM
Host
Storage
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Store at -20°C. Avoid repeated freezing and thawing
Clonality
Clone Number
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4I6-C9-F5
Isotype
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IgG
Reactivity
Application
Application Details
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ELISA: 1/1000-1/5000,WB: 1/100-1/1000,IHC-P: 1/50-1/500
Immunogen
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A synthetic peptide from the internal region of ATM which includes the mutation of R2443Q, human origin.
Formulation
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PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
Form
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Liquid
Uniprot ID
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Background
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Ataxia telangiectasia mutated (ATM) is a serine/threonine protein kinase that is recruited and activated by DNA double-strand breaks. It phosphorylates several key proteins that initiate activation of the DNA damage checkpoint, leading to cell cycle arrest, DNA repair or apoptosis. Activity of ATM protein is under tight control, and mutation of ATM can cause disease such as Ataxia telangiectasia (AT) and cancers.
Research Area
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Epigenetics and Nuclear Signaling
Synonyms
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ATM