Anti-ATM Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
-
ATM
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
R05-8D4
Isotype
-
IgG
Reactivity
Application
Application Details
-
WB: 1/500-1/1000 IP: 1/20 ChIP: 1/20
Immunogen
-
Recombinant protein of human ATM
Molecular Weight
-
Calculated MW: 351 kDa; Observed MW: 351 kDa
Formulation
-
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Form
-
Liquid
Gene ID
-
472
Uniprot ID
-
Q13315
Background
-
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability.
Research Area
-
Epigenetics and Nuclear Signaling
Synonyms
-
ATM; Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated