Anti-ATG13 Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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ATG13
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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2X9-F9-I4
Isotype
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IgG1/Kappa
Reactivity
Application
Application Details
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WB：1/500-1/1000 IHC-P：1/50-1/100
Immunogen
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Peptide
Molecular Weight
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Calculated MW: 57 kDa; Observed MW:57 kDa
Formulation
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Liquid in PBS, Glycerol and BSA
Form
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Liquid
Gene ID
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9776
Uniprot ID
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O75143
Background
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ATG13 is a protein kinase required for autophagy. Overexpression of Atg1 suppresses the defects in autophagy observed in Atg13 mutants. Autophagy requires a direct association between Atg1 and Atg13, and is inhibited by TOR-dependent phosphorylation of Atg13 under high-nutrient conditions. Similarly, mammalian Atg13 forms a complex with the Atg1 homologues ULK1/2, along with FIP200, which localizes to autophagic isolation membranes and regulates autophagosome biogenesis. mTOR phosphorylates both Atg13 and ULK1, suppressing ULK1 kinase activity and autophagy. ULK1 can directly phosphorylate Atg13 at a yet unidentified site, presumably to promote autophagy. Additional studies suggest that Atg13 and FIP200 can function independently of ULK1 and ULK2 to induce autophagy through an unknown mechanism.
Research Area
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Tumor biology
Synonyms
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KIAA0652