Anti-ASAH1 Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
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ASAH1
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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-
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IHC: 1/50-1/100
Immunogen
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Fusion protein of human ASAH1
Molecular Weight
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Calculated MW: 45 kDa; Observed MW: 45 kDa
Formulation
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pH 7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
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Liquid
Gene ID
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427
Uniprot ID
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Q13510
Background
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This gene encodes a heterodimeric protein consisting of a nonglycosylated alpha subunit and a glycosylated beta subunit that is cleaved to the mature enzyme posttranslationally. The encoded protein catalyzes the synthesis and degradation of ceramide into sphingosine and fatty acid. Mutations in this gene have been associated with a lysosomal storage disorder known as Farber disease. Multiple transcript variants encoding several distinct isoforms have been identified for this gene.
Research Area
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Signal Transduction
Synonyms
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AC; PHP; ASAH; PHP32; ACDase; SMAPME