Anti-APH1A Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
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APH1A
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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-
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IF: 1/50-1/100
Immunogen
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A synthetic peptide
Molecular Weight
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Calculated MW:29kDa
Formulation
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Liquid in PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Form
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Liquid
Gene ID
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51107
Uniprot ID
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Q96BI3
Background
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This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants.
Research Area
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Signal Transduction
Synonyms
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APH-1; APH-1A; CGI-78; 6530402N02Rik; APH1A