Anti-Alpha B Crystallin Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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CRYAB
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R06-4Z-5
Isotype
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IgG
Reactivity
Application
Application Details
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WB：1/500-1/1000 IHC-P：1/50-1/100
Immunogen
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Peptide
Molecular Weight
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Calculated MW: 20 kDa; Observed MW:22 kDa
Formulation
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Liquid in PBS, Glycerol and BSA
Form
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Liquid
Gene ID
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1410
Uniprot ID
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P02511
Background
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Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture.
Research Area
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Cell Biology
Synonyms
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HspB5, CRYAB, CRYA2, HSPB5