Anti-alpha 1 Fetoprotein Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
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AFP
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
-
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IHC: 1/50-1/100
Immunogen
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Fusion protein of human AFP
Molecular Weight
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Calculated MW: 69 kDa; Observed MW: 69 kDa
Formulation
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pH 7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
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Liquid
Gene ID
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174
Uniprot ID
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P02771
Background
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Alpha-fetoprotein (AFP) is a 65 kDa glycoprotein found in the mammalian fetal liver, yolk sac, and GI tract. In normal adult cells, p53 binds to the repressor region of the AFP gene, thereby blocking transcription. Mutations in both p53 and β-catenin are associated with aberrant expression of AFP. Research studies have shown that elevated serum AFP levels are predictive of hepatocellular carcinoma .
Research Area
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Cancer
Synonyms
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Alpha-fetoprotein; Alpha-1-fetoprotein; Alpha-fetoglobulin