Anti-ALAD Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
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ALAD
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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-
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IF: 1/50-1/200
Immunogen
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Recombinant fusion protein
Molecular Weight
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Calculated MW:36kDa
Formulation
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Liquid in PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Form
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Liquid
Gene ID
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210
Uniprot ID
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P13716
Background
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The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.
Research Area
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Cardiovascular
Synonyms
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PBGS; ALADH; ALAD