Anti-AF10 Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
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MLLT10
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
-
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000
Immunogen
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Full length fusion protein
Molecular Weight
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Calculated MW: 113 kDa; Observed MW: 113 kDa
Formulation
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pH 7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
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Liquid
Gene ID
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8028
Uniprot ID
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P55197
Background
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Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302).
Research Area
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Epigenetics and Nuclear Signaling
Synonyms
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MLLT10; AF10; Protein AF-10; ALL1-fused gene from chromosome 10 protein