Anti-ADCK3 Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
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COQ8A
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Clonality
Clone Number
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-
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000
Immunogen
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Synthetic peptide corresponding to Human ADCK3.
Molecular Weight
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Calculated MW: 72kDa
Formulation
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1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Form
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Liquid
Gene ID
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56997
Uniprot ID
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Q8NI60
Background
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CABC1 (chaperone activity of bc1 complex-like), also known as COQ8 or ADCK3 (aarF domain-containing protein kinase 3) is a 647 amino acid mitochondrial protein that belongs to the protein kinase superfamily. Ubiquitously expressed with higher expression in heart and skeletal muscle, CABC1 is thought to function as a chaperone in the proper assembly of protein complexes found in the respiratory chain. CABC1 expression is induced both in response to DNA damage and by the tumor suppressor p53. When CABC1 expression is inhibited, p53-induced apoptosis is partially suppressed, suggesting a possible role for CABC1 in tumor suppression. Mutations in the gene encoding CABC1 may
be implicated in ubiquinone deficiency, which can lead to cerebellar ataxia and seizures. Four isoforms of CABC1 exist due to alternative splicing events.
Research Area
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Synonyms
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Atypical kinase COQ8A, mitochondrial; Chaperone activity of bc1 complex-like; Chaperone-ABC1-like; Coenzyme Q protein 8A; aarF domain-containing protein kinase 3; COQ8A; ADCK3; CABC1; PP265