Anti-ADAM17 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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ADAM17
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R06-4E5
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/50 FC: 1/50-1/100
Immunogen
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A synthesized peptide derived from human ADAM17
Molecular Weight
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Calculated MW: 93 kDa
Formulation
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Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
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Liquid
Gene ID
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6868
Uniprot ID
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P78536
Background
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TACE is responsible for the shedding of EGFR ligands such as amphiregulin and TNF-α. Some tumors have hyperactivated EGFR due to upregulated TNF-α production and upregulated TACE, making TACE a potential target for drug development. TACE activates Notch in a ligand-independent manner and has been shown to play a role in the development of the Drosophila nervous system.
Research Area
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Neuroscience
Synonyms
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CD156b; ADAM17; CSVP; TACE