Anti-ADAM10 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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ADAM10
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R08-8J6
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IP: 1/50
Immunogen
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A synthesized peptide derived from human ADAM10
Molecular Weight
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Calculated MW: 84 kDa; Observed MW: 84 kDa
Formulation
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Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
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Liquid
Gene ID
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102
Uniprot ID
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O14672
Background
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The ADAM10 prodomain acts as a chaperone that stabilizes mature ADAM protein folding, and prevents target-protein shedding through inhibition of ADAM10 proteinase activity. Mature ADAM10 is the major α-secretase responsible for cleavage of Notch, APP, cadherins, and prion protein. The ADAM10 protein cleaves receptor tyrosine kinases and their associated ligands and displays a wide range of regulatory functions across related signaling pathways.
Research Area
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Cell Biology
Synonyms
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CDw156; CD156c; ADAM10; KUZ; MADM