Anti-2-Hydroxyisobutyryl-Histone H4 (Lys20) Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
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H4C1
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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-
Isotype
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IgG
Reactivity
Application
Application Details
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WB：1/500-1/1000
Immunogen
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Peptide
Molecular Weight
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-
Formulation
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Liquid in PBS, Glycerol and BSA
Form
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Liquid
Gene ID
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121504
Uniprot ID
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P62805
Background
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Histones are subjected to a variety of enzyme catalyzed modifications, including acetylation, methylation, phosphorylation, ubiquitylation, etc. 2-hydroxyisobutyrylation of lysine is a newly identified reversible modification controlling chromosome structure and gene transcription. The reversible lysine 2-hydroxyisobutyrylation has been well demonstrated in eukaryotic histones from worm to human. The unique structure and genomic localization of histone lysine 2-hydroxyisobutyrylation suggest that it is mechanistically and functionally different from histone lysine acetylation. Specifically, in both human somatic and mouse male germ cell genomes, histone 2-hydroxyisobutyrylation marks either active promoters or potential enhancers.
Research Area
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Epigenetics and Nuclear Signaling
Synonyms
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H4K20hib