Anti-Phospho-p38 (Thr180/Tyr182) Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
-
MAPK14
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
-
Isotype
-
IgG
Reactivity
Application
Application Details
-
WB: 1/500-1/1000
Immunogen
-
Peptide sequence around phosphorylation site of threonine 180 or tyrosine 182 (E-M-T(p)-G-Y(p)-V-A) derived from Human P38 MAPK.
Molecular Weight
-
Calculated MW: 41 kDa; Observed MW: 41 kDa
Formulation
-
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Form
-
Liquid
Gene ID
-
1432
Uniprot ID
-
Q16539
Background
-
Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6.
Research Area
-
Signal Transduction
Synonyms
-
MAPK14; CSBP; CSBP1; CSBP2; CSPB1; MXI2; SAPK2A; Mitogen-activated protein kinase 14; MAP kinase 14; MAPK 14; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAP kinase MXI2; MAX-interacting protein