Anti-hnRNP A1 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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HNRNPA1
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R01-2A9
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 FC: 1/50-1/100
Immunogen
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A synthesized peptide derived from human hnRNP A1
Molecular Weight
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Calculated MW: 39 kDa; Observed MW: 33 kDa
Formulation
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Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
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Liquid
Gene ID
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3178
Uniprot ID
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P09651
Background
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hnRNP A1 regulates the alternative splicing of c-Src and c-H-Ras and modifies initiation of translation of the fibroblast growth factor 2 mRNA. hnRNP A1 expression level is elevated in many cancers; knockdown of hnRNP A1 leads to apoptosis in various cancer cells. Although predominantly nuclear, hnRNP A1 is continually transported from the nucleus to the cytoplasm where it disassociates from mRNA and is rapidly re-imported into the nucleus.
Research Area
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Epigenetics and Nuclear Signaling
Synonyms
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HNRNPA 1; HNRNPA1; HNRPA1