Anti-CD33 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
-
CD33
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
R07-4Y-4
Isotype
-
IgG
Reactivity
Application
Application Details
-
IHC-P：1/50-1/100
Immunogen
-
Peptide
Molecular Weight
-
–
Formulation
-
Liquid in PBS, Glycerol and BSA
Form
-
Liquid
Gene ID
-
945
Uniprot ID
-
P20138
Background
-
Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state. Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK. These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules.
Research Area
-
Cell Biology
Synonyms
-
Siglec-3