Anti-CD31 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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PECAM1
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R07-4R-3
Isotype
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IgG
Reactivity
Application
Application Details
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WB：1/500-1/1000，IHC-P：1/50-1/100，ICC/IF：1/50，FC：1/50-1/100
Immunogen
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Peptide
Molecular Weight
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Calculated MW: 83 kDa; Observed MW:125 kDa
Formulation
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Liquid in PBS, Glycerol and BSA
Form
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Liquid
Gene ID
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5175
Uniprot ID
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P16284
Background
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Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils. Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal. Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells.
Research Area
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Tumor biology
Synonyms
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EndoCAM, GPIIA', PECA1, PECAM1, PECAM-1