Anti-CD154 Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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CD40LG
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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1C1-T2-I7
Isotype
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IgG1/Kappa
Reactivity
Application
Application Details
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FC：1/50-1/100
Immunogen
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Peptide
Molecular Weight
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–
Formulation
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Liquid in PBS, Glycerol and BSA
Form
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Liquid
Gene ID
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959
Uniprot ID
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P29965
Background
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Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation. Induces the activation of NF-kappa-B. Induces the activation of kinases MAPK8 and PAK2 in T-cells. Induces tyrosine phosphorylation of isoform 3 of CD28. Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching.
Research Area
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Tumor biology
Synonyms
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CD40LG, CD40L, TNFSF5, TRAP