Anti-Acetyl-Histone H2B (Lys46) Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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H2BC4
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R06-4B-3
Isotype
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IgG
Reactivity
Application
Application Details
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WB：1/500-1/1000
Immunogen
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Peptide
Molecular Weight
-
-
Formulation
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Liquid in PBS, Glycerol and BSA
Form
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Liquid
Gene ID
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－
Uniprot ID
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P62807
Background
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Histone post-translational modifications (PTMs) are key mechanisms of epigenetics that modulate chromatin structures, termed as “histone code”. The PTMs on histone including acetylation, methylation, phosphorylation and novel acylations directly affect the accessibility of chromatin to transcription factors and other epigenetic regulators, altering genome stability, gene transcription, etc. Histone acetylation occurs primarily at multiple lysine residues on the amino-terminal of core histones, in response to various stimuli and plays vital roles in the regulation of gene expression, DNA damage repair, chromatin dynamics, etc. Mostly, histone H2A is primarily acetylated at Lys5, 9, 15, and 36; H2B is primarily acetylated at Lys5, 12, 15,16, and 20. Histone H3 is primarily acetylated at Lys4, 9, 14, 18, 23, 27, 56, and 79. Histone H4 is primarily acetylated at Lys5, 8, 12, 16, and 20. Histone acetyltransferases (HATs) and histone deacetylases (HDACs) are major regulating factors.
Research Area
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Epigenetics and Nuclear Signaling
Synonyms
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H2BK46ac; Histone H2B.1 A；Histone H2B.a (H2B/a)；Histone H2B.g (H2B/g)；Histone H2B.h (H2B/h)；Histone H2B.k (H2B/k)；Histone H2B.l (H2B/l)