Anti-Acetyl-Histone H2A (Lys15) Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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H2AC4
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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6V5-Z6-T8
Isotype
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IgG
Reactivity
Application
Application Details
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WB：1/500-1/1000
Immunogen
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Peptide
Molecular Weight
-
-
Formulation
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Liquid in PBS, Glycerol and BSA
Form
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Liquid
Gene ID
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3012
Uniprot ID
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P04908
Background
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The ε-amino lysine acetylation of proteins is an important reversible modification controlling protein activity. The amino-terminal tails of core histones undergo lysine acetylation in multiple sites. Lysine acetylation in core histones occurs in response to various stimuli and plays vital roles in the regulation of many cellular processes including chromatin dynamics, transcription regulation, cell cycle progression, apoptosis, differentiation, and nuclear import. In most species, histone H2A is primarily acetylated at Lys5, 9, 15 and 36; H2B is primarily acetylated at Lys5, 12, 15, 16 and 20. Histone H3 is primarily acetylated at Lys4, 9, 14, 18, 23, 27, 56 and 79. Histone H4 is primarily acetylated at Lys5, 8, 12, 16 and 20. More than 20 histone acetyltransferases (HATs) and 18 histone deacetylases (HDACs) have been identified to date, while the mechanistic details of substrate selection and site specificity of these enzymes remain unclear. The regulation of histone lysine acetylation status is impaired in cancer and other patients and therefore, enzymes regulating histone lysine acetylation have become promising targets for anti-cancer drugs.
Research Area
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Epigenetics and Nuclear Signaling
Synonyms
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H2AK15ac; Histone H2A.2；Histone H2A/a；Histone H2A/m