Anti-ABCD2 Rabbit Polyclonal Antibody

Anti-ABCD2 Rabbit Polyclonal Antibody
Anti-ABCD2 Rabbit Polyclonal Antibody

Anti-ABCD2 Rabbit Polyclonal Antibody

Rabbit IgG Polyclonal for ABCD2 detection, Test with IHC-P in Human, Mouse, Rat

Reactivity
  • Human
  • Mouse
  • Rat
Application
  • IHC-P
Host
  • Rabbit
Catalog Number
    ABXB03746
$340.00

Shipping To:
United States

Product Information

Downloads & Supports

Target
    ABCD2
Host
  • Rabbit
Storage
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
  • Polyclonal
Clone Number
    -
Isotype
    IgG
Reactivity
  • Human
  • Mouse
  • Rat
Application
  • IHC-P
Application Details
    IHC: 1/50-1/100
Immunogen
    Synthetic peptide of human ABCD2
Molecular Weight
    -
Formulation
    pH 7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
    Liquid
Gene ID
    225
Uniprot ID
    Q9UBJ2
Background
    The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, accounting for the extreme variation among adrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, a genetically heterogeneous disorder of peroxisomal biogenesis.
Research Area
    Tags & Cell Markers
Synonyms
    ALDR; ABC39; ALDL1; ALDRP; hALDR
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Product Image

Immunohistochemistry analysis of paraffin-embedded Human thyroid cancer using ABCD2. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.