Anti-5T4 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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TPBG
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R05-3A0
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IP: 1/20
Immunogen
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A synthetic peptide of human 5T4
Molecular Weight
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Calculated MW: 46 kDa; Observed MW: 78 kDa
Formulation
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50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Form
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Liquid
Gene ID
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7162
Uniprot ID
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Q13641
Background
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5T4 is a 72 kDa transmembrane glycoprotein that exhibits restricted expression in human and mouse adult tissues, is upregulated on many carcinomas and tumour expression correlates with poorer clinical outcome in ovarian, gastric and colorectal cancers. mES cells lack cell surface expression of the 5T4 antigen, and both protein and mRNA are rapidly upregulated following induction of differentiation. This proteins expression correlates with downregulation of OCT-4 and Tra-1–60.
Research Area
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Stem Cells
Synonyms
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5T4; 5T4AG; M6P1; TPBG; 5T4 oncofetal antigen; Trophoblast glycoprotein