Anti-5-hydroxymethylcytosine (5-hmC) Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
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Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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Isotype
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IgG
Reactivity
Application
Application Details
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DB: 1/500-1/2000 ELISA: 1/5000-1/10000
Immunogen
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Chemical compounds corresponding to 5-hydroxymethylcytidine / hm5C.
Molecular Weight
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Formulation
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Liquid in PBS containing 0.01% thimerosal,50% glycerol,pH7.3.
Form
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Liquid
Gene ID
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Uniprot ID
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Background
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5-Hydroxymethylcytosine (5-hmC) is a modified base form of cytosine recently found in Human/mouse brain and inembryonic stem cells. This DNA pyrimidine nitrogen base can be generated by oxidation of 5-methylcytosine, a reaction mediated by the ten-eleven translocation (TET) family of the 5-mC hydroxylases. The function of this base is still not elucidated but it is believed to play an important role in switching genes on and off.
Research Area
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Epigenetics and Nuclear Signaling
Synonyms
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5-hmC; 5hmc; 5-HydroxyMethyl cytidine; hm5c