Anti-4E BP1 Rabbit Monoclonal Antibody [KO]
Product Information
Downloads & Supports
Target
-
EIF4EBP1
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
R06-8E6
Isotype
-
IgG
Reactivity
Application
Application Details
-
WB: 1/500-1/1000 IHC: 1/50-1/100 IP: 1/20
Immunogen
-
A synthetic peptide of human eIF4EBP1
Molecular Weight
-
-
Formulation
-
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
Form
-
Liquid
Gene ID
-
1978
Uniprot ID
-
Q13541
Background
-
Translation repressor protein 4E-BP1 (also known as PHAS-1) inhibits cap-dependent translation by binding to the translation initiation factor eIF4E. Hyperphosphorylation of 4E-BP1 disrupts this interaction and results in activation of cap-dependent translation. Both the PI3 kinase/Akt pathway and FRAP/mTOR kinase regulate 4E-BP1 activity.
Research Area
-
Epigenetics and Nuclear Signaling
Synonyms
-
EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I